Primary periocular squamous cell carcinoma in central Spain: Factors related to recurrence.

PURPOSE: To describe the characteristics and recurrence rates of primary periocular squamous cell carcinoma (SCC) in Spain. METHODS: This retrospective study investigates the characteristics of primary periocular SCC at two tertiary centers in Spain from 2000 to 2020. Data were collected on demographics, skin phenotype, location, clinical and histological diagnosis, the commitment of surgical margins, recurrence, and risk factors. Multivariate analysis and risk factors were used to investigate recurrence rates, considering p < 0.05 as statistically significant. RESULTS: Over the 20-year studied period, 107 patients with primary periocular SCC were assessed. The mean age of SCC was 76.8 ± 12.8 years, 55 (50.9%) were females, and 105 (98.1%) had Fitzpatrick skin phenotype type II or III. SCC lesions affected less than 1/3 of the eyelid (56/52.3% cases), mainly the lower lid (42/39.3% lesions). Sixty (56.1%) cases were SCC differentiated, 76 (71%) had clear margins. Clinical diagnosis of SCC corroborated with histological in 84 (78.5%) cases and orbital involvement occurred in 18 (16.8%) cases. Recurrence was observed in 13 (12.1%) cases, occurring more in large tumors and undifferentiated subtype (53.8%), with committed margins (69.2%) (p = 0.001), being the commitment of margins a significant predictor for recurrence, although thickness was an independent predictor. CONCLUSION: Periocular SCC in Spain showed a similar pattern as in the world. The risk of recurrence is increased in undifferentiated and large periocular SCC, partially removed with committed margins.

Afectación intestinal por un hongo dematiáceo / Intestinal disease by a dematiaceous fungi

Resumen Introducción: Los hongos dematiáceos se caracterizan por la presencia de abundante melanina en su pared celular. Presentan una distribución mundial, siendo más comunes en climas tropicales y subtropicales. Producen infecciones cutáneas y subcutáneas, además de enfermedades alérgicas, neumonías, abscesos cerebrales o infecciones diseminadas. Caso Clínico: Presentamos el caso de un paciente con adenocarcinoma de recto intervenido quirúrgicamente con hallazgo incidental de divertículo de Meckel y en el cual en el estudio anatomopatológico reveló la presencia de un hongo dematiáceo

Introduction: Dematiaceous fungi are characterized by the presence of brown melanine or melanine like pigments in their cell wall. They are generally distributed worldwide, being more common in tropical and subtropical climates. The clinical syndromes are often cutaneous and subcutaneous infections, but can be also responsible of allergic diseases, pneumonias, cerebral abscesses or disseminated infections. Clinical Case: We present the case of a patient with a diagnosis of rectal adenocarcinoma intervening surgically and with an incidental finding of Meckel's Diverticulum. The anatomopathological study revealed the presence of a dematiaceous fungi.

¿Somos lo que comemos? Un estudio sobre la composición tisular y microbiológica de la carne picada de vacuno / Are we what we eat? A study of the tissue composition and microbiology of minced beef

En los últimos años en nuestro país se ha incrementado el consumo de carne picada, como reflejo de la actual crisis económica. Con el objeto de conocer la composición tisular y microbiológica de estos preparados cárnicos, se diseñó un estudio en el que se adquirieron siete envases de carne picada de vacuno en grandes superficies elegidas al azar, en el territorio de la comunidad de Madrid. Estos casos fueron procesados de forma convencional (fijación en formol e inclusión en parafina) para realizar un examen de su composición tisular y evaluar su estado de preservación con métodos convencionales de microscopía óptica. Se procedió a realizar antes de la fijación tisular, un cultivo microbiológico adicional. Los datos obtenidos reflejan en general la existencia de productos alimentarios de baja calidad y mal preservados, contaminados frecuentemente con flora bacteriana de tipo fecal (AU)

During recent years, probably due to the economic crisis, there has been an increase in the consumption of minced beef in Spain. A study was carried out to determine the tissue and microbiological composition of the minced beef on sale. Seven packets were bought randomly from shops throughout the region of Madrid and their contents processed with formalin fixation and paraffin embedding and examined by optical microscopy to examine tissue composition and the state of preservation. A microbiological study was also carried out. We found that these meat products were of poor quality, badly preserved and frequently contaminated with faecal bacteria (AU)